Protein structure prediction meets Cryo-EM

Foundations and Applications of AI

Organizer：

Chenglong Bao 包承龙

Speaker：

Jianyi Yang（Shandong University）

Time：

Thur., 4:00-5:00 pm, Sept. 11, 2025

Venue：

C654, Shuangqing Complex Building A

Title：

Protein structure prediction meets Cryo-EM

Abstract:

AI-based methods have revolutionized protein structure prediction, yet significant challenges remain in modeling complex biomolecular assemblies, dynamic conformations, and RNA structures. In this talk, I will present CryoAtom, a novel approach that adapts AI techniques from protein structure prediction to resolve atomic structures from Cryo-EM density maps. CryoAtom is publicly available at: https://github.com/YangLab-SDU/CryoAtom.

About the speaker:

Jianyi Yang is a professor at Shandong University. He has made key contributions to the development of a few widely-used algorithms, such as trRosetta, trRosettaRNA and I-TASSER. Notably, his research group achieved outstanding success, winning the protein structure prediction challenges in both CASP15 (2022) and CASP16 (2024). With over 70 publications and approximately 20,000 citations, his work has had a profound impact on the scientific community.