Abstract:High‐throughput genomics yields vast amounts of data for personalized medicine and other health-related discoveries. For instance, genome‐wide association studies (GWAS), which involves tens of thousands to millions of subjects, have linked thousands of genetic changes or variants with human diseases. Accumulating these variants across a subjects' entire genome can help predict thei...
In statistical learning, various mathematical optimalities are used to characterize performances of different learning methods. They include minimax optimality from a worst-case standpoint and asymptotic efficiency from a rosy view that the regression function to be learned sits there to be discovered. When multiple models, e.g., trees, neural networks and support vector machines, are considere...