讲座提要：

Stem cell regeneration is a basic biological process in multicellular organisms. This talk will introduce a novel mathematical framework to model the dynamics of stem cell regeneration with cell heterogeneity and cell plasticity. The framework generalizes the classical G0 cell cycle model and incorporates the epigenetic states of individual cells represented by a continuous multidimensional variable. Based on the model, we introduce a concept of kinetotype that represents the kinetic rates of cell behaviors, including proliferation, differentiation, and apoptosis, which are dependent on the epigenetic state of each cell. The concept of kinetotype provides a connection between single cell sequencing information and macroscopic population dynamics. The proposed mathematical framework provides a generalized formula that helps us to understand various dynamic processes of stem cell regeneration, including tissue development, degeneration, and abnormal growth.

讲座人介绍：

雷锦志，天津工业大学数学科学学院、应用数学中心教授，博士生导师，天津市特聘教授。中国工业与应用数学学会数学生命科学专业委员会副主任、运筹学会计算系统生物学分会常务理事、数学学会生物数学专业委员会委员，长期从事计算生物学、生物信息学、动力系统等领域的研究工作。到目前共发表SCI论文70余篇，出版了专著两本，主持国家自然科学基金项目四项。